Use of Tear Substitutes to enhance the Image Quality of the Optic Nerve and Retina by Optical Coherence Tomography

Rai Tanvi Ravindranath; Nayak Vittal Irvathur; Alhaj Farhath Tasneem; Channabasappa Seema; Achar Myna

doi:doi:10.11648/j.ijovs.20240903.13

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Use of Tear Substitutes to enhance the Image Quality of the Optic Nerve and Retina by Optical Coherence Tomography

Rai Tanvi Ravindranath

, Nayak Vittal Irvathur^*

, Alhaj Farhath Tasneem

, Channabasappa Seema

, Achar Myna

Published in International Journal of Ophthalmology & Visual Science (Volume 9, Issue 3)

Received: 14 April 2024 Accepted: 26 August 2024 Published: 26 September 2024

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Abstract

Background & Objectives: Dry eye disease (DED) has become very prevalent, with the increased usage of internet and video terminals. The present study was carried out to compare the efficacy of tear substitutes in enhancing the signal strength of measurements of optic nerve head, retinal nerve fiber layer and macula by Optical coherence tomography (OCT), and resultant change in image quality. Thus proving the role of artificial tear substitutes in increasing the diagnostic accuracy of Optical coherence tomography (OCT) measurements. Methods: A double blinded randomized control trial was performed on one hundred and fifty patients needing optical coherence tomography. They were randomly allocated into three groups to receive any one of the three tear substitutes Group 1 –Sodium hyaluronate (Molecular Weight M Wt 799.6g/mol) Group 2 – Poly ethylene glycol (Molecular Weight M Wt 400g/mol), Group -3 Hydroxy Propyl Methyl cellulose (Molecular Weight M Wt 1261.4 g/mol); Measurement of signal strength for optic nerve head, retinal nerve fiber thickness RNFL and sub foveal thickness SFT was done before and after instillation of tear substitutes. Data was analyzed using the Statistical Package for Social Sciences SPSS 22 version software. P value <0.05 was considered statistically significant. Results: The groups were comparable with respect to mean age and gender distribution. The mean signal strength (SS) of Optic Nerve Head (ONH) evaluation improved in all the groups in both eyes. The increase was the highest in Group II in both eyes. The increase in retinal nerve fiber layer thickness [RNFL] was seen in both eyes in all the groups. Improvement in macular evaluation sub foveal thickness (SFT) was seen in Group II of both eyes and group III in the Left eye. Interpretation and Conclusion: All tear substitutes improved the quality of the image but the improvement varied with regard to the parameters measured, thus proving artificial tear application is an essential for Optical coherence tomography OCT measurements in persons prone to dry eye This reduces the scope for error due to bad images and thereby the possibility of misdiagnosis of ophthalmic disease.

Published in	International Journal of Ophthalmology & Visual Science (Volume 9, Issue 3)
DOI	10.11648/j.ijovs.20240903.13
Page(s)	46-55
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Dry Eye Disease, Optical Coherence Tomography, Signal Strength of ONH, Sub Foveal Thickness, Retinal Nerve Fiber Layer Thickness, Sodium Hyaluronate, Polyethylene Glycol, Hydroxy Propyl Methyl Cellulose

References

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[14]	Hannemann E, Erb C., The Impact of Artificial Tear Viscosity on the Results of Optical Coherence Tomography. Klin Monbl Augenheilkd. 2021; 238(9): 1004-9.
[15]	Carracedo G, Pastrana C, Serramito M, Rodriguez-Pomar C. Evaluation of tear meniscus by optical coherence tomography after different sodium hyaluronate eyedrops instillation. Acta Ophthalmol. 2019; 97(2): e162-9.
[16]	Napoli PE, Satta GM, Coronella F, Fossarello M. Spectral-domain optical coherence tomography study on dynamic changes of human tears after instillation of artificial tears. Invest Ophthalmol Vis Sci. 2014; 55(7): 4533-40.
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APA Style

Ravindranath, R. T., Irvathur, N. V., Tasneem, A. F., Seema, C., Myna, A. (2024). Use of Tear Substitutes to enhance the Image Quality of the Optic Nerve and Retina by Optical Coherence Tomography. International Journal of Ophthalmology & Visual Science, 9(3), 46-55. https://doi.org/10.11648/j.ijovs.20240903.13

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ACS Style

Ravindranath, R. T.; Irvathur, N. V.; Tasneem, A. F.; Seema, C.; Myna, A. Use of Tear Substitutes to enhance the Image Quality of the Optic Nerve and Retina by Optical Coherence Tomography. Int. J. Ophthalmol. Vis. Sci. 2024, 9(3), 46-55. doi: 10.11648/j.ijovs.20240903.13

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AMA Style

Ravindranath RT, Irvathur NV, Tasneem AF, Seema C, Myna A. Use of Tear Substitutes to enhance the Image Quality of the Optic Nerve and Retina by Optical Coherence Tomography. Int J Ophthalmol Vis Sci. 2024;9(3):46-55. doi: 10.11648/j.ijovs.20240903.13

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@article{10.11648/j.ijovs.20240903.13,
  author = {Rai Tanvi Ravindranath and Nayak Vittal Irvathur and Alhaj Farhath Tasneem and Channabasappa Seema and Achar Myna},
  title = {Use of Tear Substitutes to enhance the Image Quality of the Optic Nerve and Retina by Optical Coherence Tomography
},
  journal = {International Journal of Ophthalmology & Visual Science},
  volume = {9},
  number = {3},
  pages = {46-55},
  doi = {10.11648/j.ijovs.20240903.13},
  url = {https://doi.org/10.11648/j.ijovs.20240903.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijovs.20240903.13},
  abstract = {Background & Objectives: Dry eye disease (DED) has become very prevalent, with the increased usage of internet and video terminals. The present study was carried out to compare the efficacy of tear substitutes in enhancing the signal strength of measurements of optic nerve head, retinal nerve fiber layer and macula by Optical coherence tomography (OCT), and resultant change in image quality. Thus proving the role of artificial tear substitutes in increasing the diagnostic accuracy of Optical coherence tomography (OCT) measurements. Methods: A double blinded randomized control trial was performed on one hundred and fifty patients needing optical coherence tomography. They were randomly allocated into three groups to receive any one of the three tear substitutes Group 1 –Sodium hyaluronate (Molecular Weight M Wt 799.6g/mol) Group 2 – Poly ethylene glycol (Molecular Weight M Wt 400g/mol), Group -3 Hydroxy Propyl Methyl cellulose (Molecular Weight M Wt 1261.4 g/mol); Measurement of signal strength for optic nerve head, retinal nerve fiber thickness RNFL and sub foveal thickness SFT was done before and after instillation of tear substitutes. Data was analyzed using the Statistical Package for Social Sciences SPSS 22 version software. P value Results: The groups were comparable with respect to mean age and gender distribution. The mean signal strength (SS) of Optic Nerve Head (ONH) evaluation improved in all the groups in both eyes. The increase was the highest in Group II in both eyes. The increase in retinal nerve fiber layer thickness [RNFL] was seen in both eyes in all the groups. Improvement in macular evaluation sub foveal thickness (SFT) was seen in Group II of both eyes and group III in the Left eye. Interpretation and Conclusion: All tear substitutes improved the quality of the image but the improvement varied with regard to the parameters measured, thus proving artificial tear application is an essential for Optical coherence tomography OCT measurements in persons prone to dry eye This reduces the scope for error due to bad images and thereby the possibility of misdiagnosis of ophthalmic disease.
},
 year = {2024}
}

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TY  - JOUR
T1  - Use of Tear Substitutes to enhance the Image Quality of the Optic Nerve and Retina by Optical Coherence Tomography

AU  - Rai Tanvi Ravindranath
AU  - Nayak Vittal Irvathur
AU  - Alhaj Farhath Tasneem
AU  - Channabasappa Seema
AU  - Achar Myna
Y1  - 2024/09/26
PY  - 2024
N1  - https://doi.org/10.11648/j.ijovs.20240903.13
DO  - 10.11648/j.ijovs.20240903.13
T2  - International Journal of Ophthalmology & Visual Science
JF  - International Journal of Ophthalmology & Visual Science
JO  - International Journal of Ophthalmology & Visual Science
SP  - 46
EP  - 55
PB  - Science Publishing Group
SN  - 2637-3858
UR  - https://doi.org/10.11648/j.ijovs.20240903.13
AB  - Background & Objectives: Dry eye disease (DED) has become very prevalent, with the increased usage of internet and video terminals. The present study was carried out to compare the efficacy of tear substitutes in enhancing the signal strength of measurements of optic nerve head, retinal nerve fiber layer and macula by Optical coherence tomography (OCT), and resultant change in image quality. Thus proving the role of artificial tear substitutes in increasing the diagnostic accuracy of Optical coherence tomography (OCT) measurements. Methods: A double blinded randomized control trial was performed on one hundred and fifty patients needing optical coherence tomography. They were randomly allocated into three groups to receive any one of the three tear substitutes Group 1 –Sodium hyaluronate (Molecular Weight M Wt 799.6g/mol) Group 2 – Poly ethylene glycol (Molecular Weight M Wt 400g/mol), Group -3 Hydroxy Propyl Methyl cellulose (Molecular Weight M Wt 1261.4 g/mol); Measurement of signal strength for optic nerve head, retinal nerve fiber thickness RNFL and sub foveal thickness SFT was done before and after instillation of tear substitutes. Data was analyzed using the Statistical Package for Social Sciences SPSS 22 version software. P value Results: The groups were comparable with respect to mean age and gender distribution. The mean signal strength (SS) of Optic Nerve Head (ONH) evaluation improved in all the groups in both eyes. The increase was the highest in Group II in both eyes. The increase in retinal nerve fiber layer thickness [RNFL] was seen in both eyes in all the groups. Improvement in macular evaluation sub foveal thickness (SFT) was seen in Group II of both eyes and group III in the Left eye. Interpretation and Conclusion: All tear substitutes improved the quality of the image but the improvement varied with regard to the parameters measured, thus proving artificial tear application is an essential for Optical coherence tomography OCT measurements in persons prone to dry eye This reduces the scope for error due to bad images and thereby the possibility of misdiagnosis of ophthalmic disease.

VL  - 9
IS  - 3
ER  -

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Author Information

Rai Tanvi Ravindranath

Prasad Nethralaya, Udupi, India

Contact Email

http://orcid.org/0009-0008-7698-4081
Nayak Vittal Irvathur

Department of Ophthalmology, Vydehi Institute of Medical Sciences and Research Centre, Bangalore, India

Contact Email

http://orcid.org/0000-0002-6871-2667
Alhaj Farhath Tasneem

Department of Ophthalmology, Vydehi Institute of Medical Sciences and Research Centre, Bangalore, India

Contact Email

http://orcid.org/0009-0002-0897-0768
Channabasappa Seema

Department of Ophthalmology, Vydehi Institute of Medical Sciences and Research Centre, Bangalore, India

Contact Email

http://orcid.org/0009-0004-8510-8332
Achar Myna

Lion’s Sadhuram Postgraduate Institute of Ophthalmology, Hyderabad, India

Contact Email

http://orcid.org/0000-0002-6557-502X

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APA Style

Ravindranath, R. T., Irvathur, N. V., Tasneem, A. F., Seema, C., Myna, A. (2024). Use of Tear Substitutes to enhance the Image Quality of the Optic Nerve and Retina by Optical Coherence Tomography. International Journal of Ophthalmology & Visual Science, 9(3), 46-55. https://doi.org/10.11648/j.ijovs.20240903.13

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ACS Style

Ravindranath, R. T.; Irvathur, N. V.; Tasneem, A. F.; Seema, C.; Myna, A. Use of Tear Substitutes to enhance the Image Quality of the Optic Nerve and Retina by Optical Coherence Tomography. Int. J. Ophthalmol. Vis. Sci. 2024, 9(3), 46-55. doi: 10.11648/j.ijovs.20240903.13

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AMA Style

Ravindranath RT, Irvathur NV, Tasneem AF, Seema C, Myna A. Use of Tear Substitutes to enhance the Image Quality of the Optic Nerve and Retina by Optical Coherence Tomography. Int J Ophthalmol Vis Sci. 2024;9(3):46-55. doi: 10.11648/j.ijovs.20240903.13

Copy | Download

@article{10.11648/j.ijovs.20240903.13,
  author = {Rai Tanvi Ravindranath and Nayak Vittal Irvathur and Alhaj Farhath Tasneem and Channabasappa Seema and Achar Myna},
  title = {Use of Tear Substitutes to enhance the Image Quality of the Optic Nerve and Retina by Optical Coherence Tomography
},
  journal = {International Journal of Ophthalmology & Visual Science},
  volume = {9},
  number = {3},
  pages = {46-55},
  doi = {10.11648/j.ijovs.20240903.13},
  url = {https://doi.org/10.11648/j.ijovs.20240903.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijovs.20240903.13},
  abstract = {Background & Objectives: Dry eye disease (DED) has become very prevalent, with the increased usage of internet and video terminals. The present study was carried out to compare the efficacy of tear substitutes in enhancing the signal strength of measurements of optic nerve head, retinal nerve fiber layer and macula by Optical coherence tomography (OCT), and resultant change in image quality. Thus proving the role of artificial tear substitutes in increasing the diagnostic accuracy of Optical coherence tomography (OCT) measurements. Methods: A double blinded randomized control trial was performed on one hundred and fifty patients needing optical coherence tomography. They were randomly allocated into three groups to receive any one of the three tear substitutes Group 1 –Sodium hyaluronate (Molecular Weight M Wt 799.6g/mol) Group 2 – Poly ethylene glycol (Molecular Weight M Wt 400g/mol), Group -3 Hydroxy Propyl Methyl cellulose (Molecular Weight M Wt 1261.4 g/mol); Measurement of signal strength for optic nerve head, retinal nerve fiber thickness RNFL and sub foveal thickness SFT was done before and after instillation of tear substitutes. Data was analyzed using the Statistical Package for Social Sciences SPSS 22 version software. P value Results: The groups were comparable with respect to mean age and gender distribution. The mean signal strength (SS) of Optic Nerve Head (ONH) evaluation improved in all the groups in both eyes. The increase was the highest in Group II in both eyes. The increase in retinal nerve fiber layer thickness [RNFL] was seen in both eyes in all the groups. Improvement in macular evaluation sub foveal thickness (SFT) was seen in Group II of both eyes and group III in the Left eye. Interpretation and Conclusion: All tear substitutes improved the quality of the image but the improvement varied with regard to the parameters measured, thus proving artificial tear application is an essential for Optical coherence tomography OCT measurements in persons prone to dry eye This reduces the scope for error due to bad images and thereby the possibility of misdiagnosis of ophthalmic disease.
},
 year = {2024}
}

Copy | Download

TY  - JOUR
T1  - Use of Tear Substitutes to enhance the Image Quality of the Optic Nerve and Retina by Optical Coherence Tomography

AU  - Rai Tanvi Ravindranath
AU  - Nayak Vittal Irvathur
AU  - Alhaj Farhath Tasneem
AU  - Channabasappa Seema
AU  - Achar Myna
Y1  - 2024/09/26
PY  - 2024
N1  - https://doi.org/10.11648/j.ijovs.20240903.13
DO  - 10.11648/j.ijovs.20240903.13
T2  - International Journal of Ophthalmology & Visual Science
JF  - International Journal of Ophthalmology & Visual Science
JO  - International Journal of Ophthalmology & Visual Science
SP  - 46
EP  - 55
PB  - Science Publishing Group
SN  - 2637-3858
UR  - https://doi.org/10.11648/j.ijovs.20240903.13
AB  - Background & Objectives: Dry eye disease (DED) has become very prevalent, with the increased usage of internet and video terminals. The present study was carried out to compare the efficacy of tear substitutes in enhancing the signal strength of measurements of optic nerve head, retinal nerve fiber layer and macula by Optical coherence tomography (OCT), and resultant change in image quality. Thus proving the role of artificial tear substitutes in increasing the diagnostic accuracy of Optical coherence tomography (OCT) measurements. Methods: A double blinded randomized control trial was performed on one hundred and fifty patients needing optical coherence tomography. They were randomly allocated into three groups to receive any one of the three tear substitutes Group 1 –Sodium hyaluronate (Molecular Weight M Wt 799.6g/mol) Group 2 – Poly ethylene glycol (Molecular Weight M Wt 400g/mol), Group -3 Hydroxy Propyl Methyl cellulose (Molecular Weight M Wt 1261.4 g/mol); Measurement of signal strength for optic nerve head, retinal nerve fiber thickness RNFL and sub foveal thickness SFT was done before and after instillation of tear substitutes. Data was analyzed using the Statistical Package for Social Sciences SPSS 22 version software. P value Results: The groups were comparable with respect to mean age and gender distribution. The mean signal strength (SS) of Optic Nerve Head (ONH) evaluation improved in all the groups in both eyes. The increase was the highest in Group II in both eyes. The increase in retinal nerve fiber layer thickness [RNFL] was seen in both eyes in all the groups. Improvement in macular evaluation sub foveal thickness (SFT) was seen in Group II of both eyes and group III in the Left eye. Interpretation and Conclusion: All tear substitutes improved the quality of the image but the improvement varied with regard to the parameters measured, thus proving artificial tear application is an essential for Optical coherence tomography OCT measurements in persons prone to dry eye This reduces the scope for error due to bad images and thereby the possibility of misdiagnosis of ophthalmic disease.

VL  - 9
IS  - 3
ER  -

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