Volume 4, Issue 1, March 2019, Page: 7-13
Clinical Differences Between Nonarteritic Anterior Ischemic Optic Neuropathy and Optic Neuritis in Chinese Patients: A Retrospective Comparative Case Series Study
Jun Chen, Department of Ophthalmology, First Affiliated Hospital of Guangxi Medical University, Nanning, China; Department of Ophthalmology, Affiliated Nanping First Hospital of Fujian Medical University, Nanping, China
Wanghua Zhao, Department of Ophthalmology, First Affiliated Hospital of Guangxi Medical University, Nanning, China
Zacharia Ackbarkhan, Department of Ophthalmology, First Affiliated Hospital of Guangxi Medical University, Nanning, China
Jianfeng He, Department of Ophthalmology, First Affiliated Hospital of Guangxi Medical University, Nanning, China
Yi Du, Department of Ophthalmology, First Affiliated Hospital of Guangxi Medical University, Nanning, China
Received: Jan. 6, 2019;       Accepted: Jan. 30, 2019;       Published: Feb. 25, 2019
DOI: 10.11648/j.ijovs.20190401.12      View  164      Downloads  38
Abstract
The aim of this study is to compare the clinical features between nonarteritic anterior ischemic optic neuropathy (NAION) and optic neuritis (ON) in Chinese patients. The clinical features of 23 cases (23 eyes) of NAION and 62 cases (80 eyes) of ON, including their general conditions, manifestations, auxiliary examinations were retrospectively compared. Simultaneous onset of bilateral eye (29.03% vs. 0%, p=0.009) and pain on movement of the eyes (23.75% vs. 0%, p=0.022) were more common in ON patients in comparison to NAION patients. Ocular pain (32.5% vs. 4.35%, p=0.007) was higher in ON patients than that in NAION patients. Optic disc edema (100% vs. 62.5%, p<0.001), peripapillary hemorrhage (47.83% vs. 10%, p<0.001) and peripapillary hard exudates (17.39% vs. 1.25%, p=0.009) in NAION patients were more common compared to ON patients,. During fluorescein angiography, the rates of the partial or whole papillary hypofluorescent in early phase (65.21% vs. 22.86%, p<0.001), peripapillary choroidal filling delay (73.91% vs. 14.29%, p<0.001) and partial papillary hyperfluorescent in later phase (52.17% vs. 25.71%, p=0.019) were higher in NAION patients than those in ON patients. The clinical features of NAION and ON in Chinese patients reveal a surprising overlap and they still have some characteristic clinical features that can be utilized to differentiate the two diseases.
Keywords
Nonarteritic Anterior Ischemic Optic Neuropathy, Optic Neuritis, Retrospective Study, Chinese Patients, Distinct Features
To cite this article
Jun Chen, Wanghua Zhao, Zacharia Ackbarkhan, Jianfeng He, Yi Du, Clinical Differences Between Nonarteritic Anterior Ischemic Optic Neuropathy and Optic Neuritis in Chinese Patients: A Retrospective Comparative Case Series Study, International Journal of Ophthalmology & Visual Science. Vol. 4, No. 1, 2019, pp. 7-13. doi: 10.11648/j.ijovs.20190401.12
Copyright
Copyright © 2019 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Reference
[1]
Rizzo JF, 3rd, Lessell S. Optic neuritis and ischemic optic neuropathy. Overlapping clinical profiles [J]. Arch Ophthalmol. 1991; 109(12): 1668-1672.
[2]
Wilhelm H, Schabet M. The Diagnosis and Treatment of Optic Neuritis [J]. Dtsch Arztebl Int. 2015; 112(37): 616-625; quiz 626.
[3]
Jianu DC, Jianu SN, Petrica L, et al. Clinical and color Doppler imaging features of one patient with occult giant cell arteritis presenting arteritic anterior ischemic optic neuropathy [J]. Rom J Morphol Embryol. 2016, 57(2): 579-583.
[4]
Nagia L, Huisingh C, Johnstone J, et al. Peripapillary Pachychoroid in Nonarteritic Anterior Ischemic Optic Neuropathy [J]. Invest Ophthalmol Vis Sci. 2016; 57(11): 4679-4685.
[5]
Du Y, Li K, Yang J, et al. Disc swelling and mild initial visual acuity loss predict a better short-term visual acuity outcome in bilateral acute optic neuritis [J]. J Clin Neurosci. 2012; 19(10): 1380-1382.
[6]
Du Y, Yang J, Li JJ, et al. Unilateral optic neuritis in a Chinese population in three centers [J]. J Clin Neurosci. 2011; 18(7): 902-904.
[7]
Swartz NG, Beck RW, Savino PJ, et al. Pain in anterior ischemic optic neuropathy [J]. J Neuroophthalmol. 1995, 15(1): 9-10.
[8]
Neuro-ophthalmology Group of Chinese Ophthalmological Society. Diagnosis and treatment of optic neuritis expert consensus (2014). Zhonghua Yan Ke Za Zhi. 2014; (6): 459-463. (Chinese).
[9]
Neuro-ophthalmology Group of Chinese Ophthalmological Society. Diagnosis and treatment of nonarteritic anterior ischemic optic neuropathy expert consensus (2015). Zhonghua Yan Ke Za Zhi. 2015; 51(5): 323-326. (Chinese).
[10]
Hayreh SS. Ischaemic optic neuropathy [J]. Indian J Ophthalmol. 2000; 48(3): 171-194.
[11]
Hayreh SS, Jonas JB, Zimmerman MB. Nonarteritic anterior ischemic optic neuropathy and tobacco smoking [J]. Ophthalmology. 2007; 114(4): 804-809.
[12]
Kerr NM, Chew SS, Danesh-Meyer HV. Non-arteritic anterior ischaemic optic neuropathy: a review and update [J]. J Clin Neurosci. 2009; 16(8): 994-1000.
[13]
de la Cruz J, Kupersmith MJ. Clinical profile of simultaneous bilateral optic neuritis in adults [J]. Br J Ophthalmol. 2006; 90(5): 551-554.
[14]
Beck RW, Cleary PA, Anderson MM, Jr., et al. A randomized, controlled trial of corticosteroids in the treatment of acute optic neuritis. The Optic Neuritis Study Group [J]. N Engl J Med. 1992; 326(9): 581-588.
[15]
Shin SY, Kim DS, Ko MK. Fluorescein angiographic features of choroidal insufficiency in anterior ischemic optic neuropathy. Korean J Ophthalmol. 1999; 13(2): 100-4.
[16]
Arnold AC. Fluorescein angiographic characteristics of the optic disc in ischemic and glaucomatous optic neuropathy. Curr Opin Ophthalmol. 1995; 6(2): 30-5.
[17]
Kim MK, Kim US. Analysis of Fundus Photography and Fluorescein Angiography in Nonarteritic Anterior Ischemic Optic Neuropathy and Optic Neuritis. Korean J Ophthalmol. 2016; 30(4): 289-94.
[18]
Hayreh SS. Ischemic optic neuropathies - where are we now. Graefes Arch Clin Exp Ophthalmol. 2013; 251(8): 1873-84.
[19]
Hayreh SS, Zimmerman B. Visual field abnormalities in nonarteritic anterior ischemic optic neuropathy: their pattern and prevalence at initial examination. Arch Ophthalmol. 2005; 123(11): 1554-62.
[20]
Berninger TA, Heider W. Electrophysiology and perimetry in acute retrobulbar neuritis. Doc Ophthalmol. 1989; 71(3): 293-305.
[21]
Takasoh M, Mizota A, Adachi-Usami E. Comparative studies on pattern VECP between patients with ischemic optic neuropathy and optic neuritis. Acta Ophthalmol Scand. 2000; 78(4): 407-10.
[22]
Janaky M, Fulop Z, Palffy A, et al. Electrophysiological findings in patients with nonarteritic anterior ischemic optic neuropathy. Clin Neurophysiol. 2006; 117(5): 1158-66.
[23]
Atilla H, Tekeli O, Ornek K, et al. Pattern electroretinography and visual evoked potentials in optic nerve diseases. J Clin Neurosci. 2006; 13(1): 55-9.
[24]
Mukartihal G, Radhakrishnan S, Ramasubba RM, et al. Statistical analysis of visual evoked potentials in optic neuritis and ischemic optic neuropathy subjects. Conf Proc IEEE Eng Med Biol Soc. 2005; 2: 1193-5.
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