Volume 4, Issue 1, March 2019, Page: 14-18
The Current Status and New Research Progress of Keratoconus Treatment
Ren Fengyue, Department of Medical College, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, China
He Shuxi, Center for Ophthalmic Optics, Hunan Provincial People's Hospital, Changsha, China
Received: Jan. 28, 2019;       Accepted: Mar. 13, 2019;       Published: Apr. 13, 2019
DOI: 10.11648/j.ijovs.20190401.13      View  149      Downloads  18
Abstract
Keratoconus is a common non-inflammatory, bilateral progressive corneal dilatation disease, often leading to progressive thinning of the corneal stromal layer, the central region of the cornea is conical, clinical manifestations of high myopia and irregular astigmatism, The normal life of the patient is greatly inconvenient. Therefore, timely and effective treatment is extremely important to improve the visual quality of patients and their physical and mental health. In the early stage of the patient, vision correction can be performed by wearing a frame mirror or a contact lens; as the lesion progresses, the former is insufficient for correction, and corneal stroma implantation, corneal collagen cross-linking, and keratoplasty are feasible. Numerous studies have confirmed that this treatment can effectively improve and maintain the visual quality of patients. In recent years, new treatment methods such as matrix regeneration, matrix lens transplantation and scleral mirror have gradually become research hotspots at home and abroad. This article reviews the current major treatments for keratoconus and its new developments.
Keywords
Keratoconus, Treatment Method, Research Progress
To cite this article
Ren Fengyue, He Shuxi, The Current Status and New Research Progress of Keratoconus Treatment, International Journal of Ophthalmology & Visual Science. Vol. 4, No. 1, 2019, pp. 14-18. doi: 10.11648/j.ijovs.20190401.13
Copyright
Copyright © 2019 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Reference
[1]
Wu Dongfang, Zhang Xiaolan, Qiu Lemei. Diagnosis and treatment of keratoconus. New progress in ophthalmology. 2012, 32(12):1197-1200
[2]
Scheschy U, Scheschy H. Langzeit-Verlaufsbeobachtung des Keratoconus bei Unilateralität [J]. Spektrum Augenheilkd, 2014, 29(3): 109-117
[3]
Xie Peiying. Prevalence and clinical symptoms of keratoconus [J]. China Optical Technology Magazine, 2010, 5:529
[4]
Weed KH. The variable expression of keratoconus within monozygotic twins: Dundee university scottish keratoconus study(DUSKS). Contact Lens Anterior Eye 2006;29:123–126
[5]
Tao X, Yu H, Zhang Y, et al. Role of corneal epithelium in riboflavin/ultraviolet-A mediated corneal cross-linking treatment in rabbit eyes [J]. Biomed Res Int. 2013, 2013:624563
[6]
Davidson AE, Hayes S, Hardcastle AJ, et al. The pathogenesis of keratoconus. Eye. 2014, 28(2):189-195
[7]
Zhang Y, Mao X, Schwend T, et al. Resistance of corneal RFUVA-cross-linked collagens and small leucine-rich proteoglycans to degradation by matrix metalloproteinases. Invest Ophthalmol Vis Sci 2013; 54( 2): 1014-1025
[8]
Yang Yang, Jiang Aimin. Classification and early diagnosis of keratoconus. Chinese Journal of Ophthalmology. 2015, 5(4):213-218
[9]
Qiao Shining. Therapeutic effect of rigid gas permeable contact lens on mild to moderate keratoconus. Shenzhen Journal of Integrated Traditional Chinese and Western Medicine. 2017, 27(2):6-8
[10]
Wu Y, Tan Q, Zhang W, et al. Rigid gas-permeable contact lens related life quality in keratoconic patients with different grades of severity. Clin Exp Optom. 2015, 98(2): 150-154
[11]
Linebarger EJ, Song D, Ruckhofer J, et al. Intaes: the intrastromal corneal ring [J]. Int Ophthalmol Clin. 2000, 40:199-208
[12]
Colin J, Cochener B, Savary G, et al. INTACS inserts for treating keratoconus: one-year results [J]. ophthalmology. 2001, 108:1409-1414
[13]
Tomalla M, Cagnolati W. Modern treatment options for the therapy of keratoconus [J]. Cont Lens Anterior Eye. 2007, 30( 1): 61-66
[14]
Abdullhamid Alghamdi. Evaluation of clinical effectiveness of intrastromal corneal ring segments among keratoconus patients. Guoji Yanke Zazhi(Int Eye Sci)2018, 18(8): 1365-1369
[15]
Zhou Hongjian, Wen Feng, Lu Bing, et al. Therapeutic effect of femtosecond laser assisted penetrating keratoplasty. International journal of Ophthalmology. 2014; 14( 10): 1822-1824
[16]
Liu H, Chen Y, Wang P, et al. Efficacy and safety of deep anterior lamellar keratoplasty, vs. penetrating keratoplasty for keratoconus:a Meta•analysis. PLOS One. 2015, 10(1):1-14
[17]
Jin AC, Min AL. Kim MS. Long-term outcomes of penetrating keratoplasty in keratoconus:analysis of the factors associated with final visual acuities. Int J Ophthalmol. 2014, 7(3):517-521
[18]
Romano V, lovieno A, Parente G, et al. Long-term clinical out-comes of deep anterior lamellar keratoplasty in patients with keratoconus. Am J Ophthalmol. 2015. 159(3):505-511
[19]
Mosca L, Fasciani R, Tamburelli C, et al. Femtosecond laser-assisted lamellar keratoplasty:Early results [J]. Cornea. 2008, 27:668-672
[20]
Lu Yan, Duan Yixian, Chen Xianfei, et al. Femtosecond laser-assisted deep-layer bed study [J]. Chinese Journal of Ophthalmology. 2014, 50(4):267-272
[21]
Kim JH, Choi SK, Lee D. The comparison of fomtosecond laser-assisted penetrating keratoplasty with conventional surgery in terms of endothelial safety: ex vivo study using porcine eyes [J]. Cornea. 2009, 28:812-816
[22]
Yildirim A, Cakir H, Kara N, et al. CorneM collagen crosslinking for ectasia after laser in situ keratomilesis: long-term results. J Cataract Refract Surg, 2014, 40: 1591-1596
[23]
Hafezi F, Mrochen M, Iseli HP, Seiler T. Collagen cross linking with ultraviolet-A and hypoosmolar riboflavin solution in thin corneas [J]. J Cataract Refract Surg. 2009, 35( 4):621-624
[24]
Krueger RR, Herekar S, Spoerl E. First proposed efficacy study of high versus standard irradiance and fractionated riboflavin/uhtraviolet a cross--linking with equivalent energy exposure. Eye Contact Lens. 2014, 40:353-357
[25]
Coskunseven E, Jankov MR 2nd, Hafezi F, Atun S, Arslan E, Kymionis GD. Effect of treatment sequence in combined intrastromal corneal rings and corneal collagen crosslinking for keratoconus [J]. J Cataract Refract Surg. 2009, 35( 12):2084-2091
[26]
Li Tao, Lu Zhiyu, Yan Pisong, et al. Clinical application of corneal biomechanics. International Ophthalmology Overview. 2017, 41(6):409-413
[27]
Lwigale PY, Cressy PA, Bronner -Fraser M. Corneal keratocytes retain neural crest progenitor cell properties [J]. Dev Biol, 2005, 288:284-293
[28]
Pradhan KR, Reinstein DZ, Carp GI. et al. Femtosecond 1aser-assisted keyhole endokeratophakia: correction of hyperopia by implantation of an allogeneie lenticule obtained by SMILE from a myopic donor [J]. J Refract Surg. 2013, 29(11): 777-782
[29]
Melissa Barnett, Vivian Lien, Jennifer Y. Use of Scleral Lenses and Miniscleral Lenses After Penetrating Keratoplasty. Eye & Contact Lens. 2016;42: 185-189
[30]
Jennifer S. Harthan. Therapeutic use of mini-scleral lenses in a patient with Graves’ophthalmopathy. J Optom. 2014, 7(1):62-6
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