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Bilateral Metastases of Colorectal Cancer to the Choroid and Optic Disc
Caleb Roy Walker,
David Alan Reichstein
Issue:
Volume 2, Issue 3, August 2017
Pages:
65-68
Received:
28 February 2017
Accepted:
22 April 2017
Published:
12 June 2017
DOI:
10.11648/j.ijovs.20170203.11
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Abstract: Introduction: Metastatic colorectal cancer is highly fatal disease. While metastases are usually found in the thoracic cavity in colorectal cancer, the choroid has been shown to harbor metastases. The retrobuorbital pathway, although rarely, has also demonstrated colorectal metastases. Case report: A 54-year-old male with a one-year history of disseminated colon cancer presented with vision loss in his right eye in October 2013. A choroidal metastasis was found extending from the optic disc toward the fovea, Initial treatment consisted of systemic chemotherapy, supplemented by External Beam Radiation Therapy to the right eye one year after diagnosis. Thirteen months later, the left eye was found to have a choroidal tumor surrounding the disc. The cancer progressed through both local and systemic treatment. Discussion: While the disease progressed through multiple rounds of chemotherapy, external beam radiation therapy was shown to be effective in regressing the tumors. Managing refractory metastatic disease presents unique challenges in properly prioritizing therapeutic routes.
Abstract: Introduction: Metastatic colorectal cancer is highly fatal disease. While metastases are usually found in the thoracic cavity in colorectal cancer, the choroid has been shown to harbor metastases. The retrobuorbital pathway, although rarely, has also demonstrated colorectal metastases. Case report: A 54-year-old male with a one-year history of diss...
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Analytical Method Development and Validation of Simultaneous Estimation of Paracetamol, Aceclofenac and Serratiopeptidase by RP-HPLC
Bhavani Podili,
Mohan Seelam,
Prasada Rao Kammela
Issue:
Volume 2, Issue 3, August 2017
Pages:
69-74
Received:
30 March 2017
Accepted:
24 April 2017
Published:
19 June 2017
DOI:
10.11648/j.ijovs.20170203.12
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Abstract: In this study, high performance chromatographic method have been developed and validated for the estimation of Paracetamol (PC), Aceclofenac (AF), and Serratio peptidase (SP) in combined tablet dosage form. The chromatography was carried out on a phenomenex C18 (Luna) coloumn (250mmX 4.6mm, 5µm) with a mobile phase consisting of buffer containing 1gm heptanesulfonic acid in 1lit water (adjusted to pH 2.5 with ortho phosphoric acid) acetonitrile (90:10 v/v) at a flow rate of 1.0 mL/min and ultraviolet detection at 226 nm. The retention time of PC, AF and SP were 3.119, 7.196 and 13.560 minutes respectively. Validation of the proposed method was carried out according to International Conference on Harmonisation (ICH) guidelines. Linearity range was obtained for PC, AF and SPover the concentration range of 2.1-31.5, 0.66-9.90 and 0.1-1.5 µg/mL and the r2 values were 0.9995, 0.9998 and 0.9992 respectively. The calculate limit of detection (LOD) values were 0.21, 0.066, and 0.01µg/mL and limit of quantitation (LOQ) values were 0.42, 0.132 and 0.02µg/mL for PC, AF, and SP correspondingly.
Abstract: In this study, high performance chromatographic method have been developed and validated for the estimation of Paracetamol (PC), Aceclofenac (AF), and Serratio peptidase (SP) in combined tablet dosage form. The chromatography was carried out on a phenomenex C18 (Luna) coloumn (250mmX 4.6mm, 5µm) with a mobile phase consisting of buffer containing 1...
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Preservation of Local Grain Legume Species for Food in Bulgaria
Siyka Angelova Angelova,
Mariya Ivanova Sabeva
Issue:
Volume 2, Issue 3, August 2017
Pages:
75-79
Received:
23 March 2017
Accepted:
13 May 2017
Published:
6 July 2017
DOI:
10.11648/j.ijovs.20170203.13
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Abstract: In connection with IPGR participation in various national and international projects during the recent years, investigations have been conducted, in order to create a database of available old plant materials of grain legumes of Bulgarian origin. Different areas throughout Bulgaria with diverse relief, soil and climatic conditions have been visited. From the literature review and collected from previous studies data we identified the specific areas these crops occupy traditionally in the home garden and are sentimentally linked to family traditions. Questionnaires were developed, which intended to complement and update the existing information about location, farmer’s name, number cultivated species, usage, cooking recipes and storage. In this respect, numerous interviews with local people were conducted and were visited community centers, museums, schools and other organizations and institutions.
Abstract: In connection with IPGR participation in various national and international projects during the recent years, investigations have been conducted, in order to create a database of available old plant materials of grain legumes of Bulgarian origin. Different areas throughout Bulgaria with diverse relief, soil and climatic conditions have been visited...
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